In a groundbreaking exploration into the intricate relationship between coronary heart disease (CHD) and dementia, a large-scale observational study draws from the rich data reservoir of the UK Biobank, involving over 500,000 participants. This comprehensive investigation unveils a concerning correlation, spotlighting the heightened vulnerability of adults diagnosed with CHD to the spectrum of dementia, including all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VD). The stakes intensify when CHD manifests before the age of 45, amplifying the risk by a staggering 36%.